Organelles transport in health and disease

8:00 - 9:00 (1h)

Registration and welcome coffee break

Room Platine 1

9:00 - 12:05 (3h05)

Metabolism

Room Platine 2

Roberto Zoncu and Anja Zeigerer

9:00 - 9:10 (10min)

Welcome and introduction

Room Platine 2

Chiara Scaramuzzino, Marta Prieto and Anthony Procès

9:10 - 9:50 (40min)

From intracellular transport to metabolic activity: pleiotropic functions of mitochondria in axonal development

Room Platine 2

Julien Courchet

9:50 - 10:30 (40min)

Coupling endosomal trafficking with liver metabolism

Room Platine 2

Anja Zeigerer

10:30 - 11:05 (35min)

Coffee break

Room Platine 1

10:30 - 11:05 (35min)

Poster Session

Room Platine 1

11:05 - 11:45 (40min)

Dissecting and disabling cholesterol-mTORC1 signaling in neurodegeneration

Room Platine 2

Roberto Zoncu

11:45 - 12:00 (15min)

Creatine Kinase provides energy for the retrograde axonal transport of signaling endosomes

Room Platine 2

Myriam Saliba

12:00 - 12:10 (10min)

HuntX Pharma : the first company to address the restoration of axonal transport as a therapeutic target

Room Platine 2

HuntX Pharma - Laure Jamot, CEO

12:10 - 13:20 (1h10)

Lunch

Room Platine 1

12:10 - 13:20 (1h10)

Poster session

Room Platine 1

13:20 - 13:30 (10min)

RNAscope ISH assay to highlight the cellular and subcellular distribution of RNAs in cells and tissues

Room Platine 2

Ludovic Arnold from Bio-Techne

13:30 - 18:00 (4h30)

Neuroscience

Room Platine 2

Marina Mikhaylova and Max Koppers

13:30 - 14:10 (40min)

Energy supply for axonal transport of vesicles by glycolysis is a crucial determinant of neurodegeneration in health and Huntington disease

Room Platine 2

Frédéric Saudou

14:10 - 14:50 (40min)

Local role of the endoplasmic reticulum in organizing axonal protein synthesis

Room Platine 2

Max Koppers

14:50 - 15:05 (15min)

Impact of lysosomal PLD3 dysfunction on axonal trafficking and synaptic dynamics in the hippocampal CA3 region

Room Platine 2

Zoë Van Acker

15:05 - 15:50 (45min)

Coffee break

Room Platine 1

15:05 - 15:50 (45min)

Poster session

Room Platine 1

15:50 - 16:30 (40min)

Synaptic control of secretory organelle localisation in neurons

Room Platine 2

Marina Mikhaylova

16:30 - 16:45 (15min)

The Contribution of AP-1γ2 to the Early-to-Late Endosome Maturation and Extracellular Vesicles Release

Room Platine 2

Lucas Alves Tavares

16:45 - 17:00 (15min)

Break and group photo

17:00 - 18:00 (1h)

Lipid switches in cell physiology: From nutrient signals to disease

Room Platine 2

Volker Haucke

19:30 - 23:30 (4h)

Gala dinner at Ciel Rooftop (Bastille, Grenoble)

	Tue. 03	Wed. 04
08:00 09:00 10:00 11:00 12:00 13:00 14:00 15:00 16:00 17:00 18:00 19:00 20:00 21:00 22:00 23:00	Registration and welcome coffee break 8:00 - 9:00 (1h) Registration and welcome coffee break Room Platine 1 Metabolism Welcome and introduction From intracellular transport to metabolic activity: pleiotropic functions of mitochondria in axonal development Coupling endosomal trafficking with liver metabolism Coffee break Poster Session Dissecting and disabling cholesterol-mTORC1 signaling in neurodegeneration Creatine Kinase provides energy for the retrograde axonal transport of signaling endosomes HuntX Pharma : the first company to address the restoration of axonal transport as a therapeutic target 9:00 - 12:05 (3h05) Metabolism Room Platine 2 Roberto Zoncu and Anja Zeigerer 9:00 - 9:10 (10min) Welcome and introduction Room Platine 2 Chiara Scaramuzzino, Marta Prieto and Anthony Procès 9:10 - 9:50 (40min) From intracellular transport to metabolic activity: pleiotropic functions of mitochondria in axonal development Room Platine 2 Julien Courchet 9:50 - 10:30 (40min) Coupling endosomal trafficking with liver metabolism Room Platine 2 Anja Zeigerer 10:30 - 11:05 (35min) Coffee break Room Platine 1 10:30 - 11:05 (35min) Poster Session Room Platine 1 11:05 - 11:45 (40min) Dissecting and disabling cholesterol-mTORC1 signaling in neurodegeneration Room Platine 2 Roberto Zoncu 11:45 - 12:00 (15min) Creatine Kinase provides energy for the retrograde axonal transport of signaling endosomes Room Platine 2 Myriam Saliba 12:00 - 12:10 (10min) HuntX Pharma : the first company to address the restoration of axonal transport as a therapeutic target Room Platine 2 HuntX Pharma - Laure Jamot, CEO Lunch Poster session 12:10 - 13:20 (1h10) Lunch Room Platine 1 12:10 - 13:20 (1h10) Poster session Room Platine 1 RNAscope ISH assay to highlight the cellular and subcellular distribution of RNAs in cells and tissues 13:20 - 13:30 (10min) RNAscope ISH assay to highlight the cellular and subcellular distribution of RNAs in cells and tissues Room Platine 2 Ludovic Arnold from Bio-Techne Neuroscience Energy supply for axonal transport of vesicles by glycolysis is a crucial determinant of neurodegeneration in health and Huntington disease Local role of the endoplasmic reticulum in organizing axonal protein synthesis Impact of lysosomal PLD3 dysfunction on axonal trafficking and synaptic dynamics in the hippocampal CA3 region Coffee break Poster session Synaptic control of secretory organelle localisation in neurons The Contribution of AP-1γ2 to the Early-to-Late Endosome Maturation and Extracellular Vesicles Release Break and group photo Lipid switches in cell physiology: From nutrient signals to disease 13:30 - 18:00 (4h30) Neuroscience Room Platine 2 Marina Mikhaylova and Max Koppers 13:30 - 14:10 (40min) Energy supply for axonal transport of vesicles by glycolysis is a crucial determinant of neurodegeneration in health and Huntington disease Room Platine 2 Frédéric Saudou 14:10 - 14:50 (40min) Local role of the endoplasmic reticulum in organizing axonal protein synthesis Room Platine 2 Max Koppers 14:50 - 15:05 (15min) Impact of lysosomal PLD3 dysfunction on axonal trafficking and synaptic dynamics in the hippocampal CA3 region Room Platine 2 Zoë Van Acker 15:05 - 15:50 (45min) Coffee break Room Platine 1 15:05 - 15:50 (45min) Poster session Room Platine 1 15:50 - 16:30 (40min) Synaptic control of secretory organelle localisation in neurons Room Platine 2 Marina Mikhaylova 16:30 - 16:45 (15min) The Contribution of AP-1γ2 to the Early-to-Late Endosome Maturation and Extracellular Vesicles Release Room Platine 2 Lucas Alves Tavares 16:45 - 17:00 (15min) Break and group photo 17:00 - 18:00 (1h) Lipid switches in cell physiology: From nutrient signals to disease Room Platine 2 Volker Haucke Gala dinner at Ciel Rooftop (Bastille, Grenoble) 19:30 - 23:30 (4h) Gala dinner at Ciel Rooftop (Bastille, Grenoble)	Welcome coffee 8:30 - 9:00 (30min) Welcome coffee Room Platine 1 Cell Biology TBD GlycoSwitches control glycolipid-lectin driven endocytosis Regulation of growth factor signalling via membrane contact sites How endolysosomal super-organelles manage protein aggregates in the acentrosomal mouse oocyte Coffee break Poster session What goes in, sometimes comes out: developing molecular toolboxes to study the loading, maturation and fate of Multivesicular Bodies Investigating the role of the protein arginine methyltransferase PRMT4/CARM1 in the regulation of vesicle trafficking in triple-negative breast cancer 9:00 - 12:15 (3h15) Cell Biology Room Platine 2 Frederik Verweij and Sara Sigismund 9:00 - 9:10 (10min) TBD Room Platine 2 Proteintech 9:10 - 9:50 (40min) GlycoSwitches control glycolipid-lectin driven endocytosis Room Platine 2 Ludger Johannes 9:50 - 10:30 (40min) Regulation of growth factor signalling via membrane contact sites Room Platine 2 Sara Sigismund 10:30 - 10:45 (15min) How endolysosomal super-organelles manage protein aggregates in the acentrosomal mouse oocyte Room Platine 2 Gabriele Zaffagnini 10:45 - 11:20 (35min) Coffee break Room Platine 1 10:45 - 11:20 (35min) Poster session Room Platine 1 11:20 - 12:00 (40min) What goes in, sometimes comes out: developing molecular toolboxes to study the loading, maturation and fate of Multivesicular Bodies Room Platine 2 Frederik Verweij 12:00 - 12:15 (15min) Investigating the role of the protein arginine methyltransferase PRMT4/CARM1 in the regulation of vesicle trafficking in triple-negative breast cancer Room Platine 2 Sonia Ruggiero Lunch Poster session 12:15 - 13:20 (1h05) Lunch Room Platine 1 12:15 - 13:20 (1h05) Poster session Room Platine 1 Biophysics and Structural Biology TBD Membrane curvature and surface tension as cellular information for protein targeting in the cell Archaea Asgard reveals the conserved principles of ESCRT-III membrane remodeling Perilipin 4, a novel amyloid-forming protein implicated in skeletal muscle degeneration Coffee break Poster session Remote Control of Signaling through Caveolae Mechanics: A new paradigm in mechanotransduction Bioengineered condensates to interact and manipulate membranebound organelles in cells Concluding remarks and announcement of poster prize 13:20 - 17:00 (3h40) Biophysics and Structural Biology Room Platine 2 Aurélien Roux and Christophe Lamaze 13:20 - 13:30 (10min) TBD Room Platine 2 3i Intelligent Imaging - Osnath Assayag 13:30 - 14:10 (40min) Membrane curvature and surface tension as cellular information for protein targeting in the cell Room Platine 2 Bruno Antonny 14:10 - 14:50 (40min) Archaea Asgard reveals the conserved principles of ESCRT-III membrane remodeling Room Platine 2 Aurélien Roux 14:50 - 15:05 (15min) Perilipin 4, a novel amyloid-forming protein implicated in skeletal muscle degeneration Room Platine 2 Nicolas Fuggela 15:05 - 15:50 (45min) Coffee break Room Platine 1 15:05 - 15:50 (45min) Poster session Room Platine 1 15:50 - 16:30 (40min) Remote Control of Signaling through Caveolae Mechanics: A new paradigm in mechanotransduction Room Platine 2 Christophe Lamaze 16:30 - 16:45 (15min) Bioengineered condensates to interact and manipulate membranebound organelles in cells Room Platine 2 Emma Pasquier 16:45 - 17:00 (15min) Concluding remarks and announcement of poster prize Room Platine 2 Chiara Scaramuzzino, Marta Prieto and Anthony Procès Wine & Cheese 17:00 - 20:30 (3h30) Wine & Cheese Room Platine 1